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Meet the Researchers Striving for a Breakthrough in Osteosarcoma Treatment

Osteosarcoma is the most common pediatric bone cancer. The disease spreads quickly, and available treatments are toxic and often ineffective. Stay up to date with the researchers who are on a mission to change that.

Dr. Isidro Cortés-Ciriano (center) and his lab at the European Molecular Biology Laboratory

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Osteosarcoma Statistics

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Osteosarcoma is the most common childhood bone cancer.
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No new treatments have been approved for osteosarcoma patients in 40 years.
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1 in 3 children with osteosarcoma will not survive.

Meet the Researchers

To find a cure for osteosarcoma, we have to collaborate, innovate, and translate around the most promising science. The OSI works collaboratively with academic, medical, pharmaceutical, and philanthropic communities to develop the scientific landscape around osteosarcoma.

Will tumor profiling yield more precise treatments?

Strategic Advisory Board member Katherine Janeway, MD, MMSc, explains what precision oncology is, and how researchers are bridging gaps in precision treatment for osteosarcoma.

Can combination therapies topple metastatic osteosarcoma?

Osteosarcoma researcher Jason T. Yustein, MD, PhD, seeks to better understand the disease by testing various combinations of drugs to treat it.

Can we train immune responses to attack osteosarcoma?

OSI grant winner Daniel Vallera, PhD, is researching a promising experimental osteosarcoma treatment intended to multiply the immune system’s “first responders” to combat osteosarcoma in dogs and humans.

Where is this complex cancer’s weak spot?

Award-winning researcher Isidro Cortés-Ciriano, PhD, explains how his work seeks to better understand osteosarcoma’s genomic instability to uncover novel treatments for the most aggressive types of the disease.

Bench to Bedside: The Drug Development Process

Moving medicines from bench to bedside is critical in treating patients with all kinds of diseases and medical conditions. “Bench to bedside” research refers to a medical discovery or innovation that is translated from the research setting to the clinical setting. Another common term for this is “translational research.”

While there have been many strides in cancer-fighting drugs over the last several decades, treatment for osteosarcoma, a rare bone cancer that primarily affects children and adolescents, has remained nearly the same for the last 40 years.

Our Impact

$6.8M

Our Grant Cycle

1 Submission of Letters of Intent (LOI)

2 Expert Review of LOIs

3 Applicant Feedback and Full Proposal Invitations

4 Final Expert Review

5 Award Decisions

Patient Stories

Scott Shockley playing baseball
Homecoming King Leaves Lasting Impression on His Community

Scott Shockley was a star athlete throughout high school, but his real legacy was his care for others.

Lewis Smith and sister Jasmine Smith, MD
A Career Dedicated to Her Brother

Jasmine Smith, MD, knew she wanted to be a doctor, but she only decided on pediatric oncology as her specialty after her younger brother was diagnosed with osteosarcoma.

The Bright family
After Son’s Remission, a Mom Faces Caregiver Trauma

Even after receiving the good news that her son is in remission from osteosarcoma, Sarah Bright still feels lasting scars from the diagnosis.

Who We Work With

At the Osteosarcoma Institute, we care about progress — not who gets the credit. We collaborate with organizations throughout the cancer and sarcoma spaces.

“Communication between scientists is absolutely key to discovery. That is what has impressed me about the OSI. They have created a platform where scientists and clinicians are brought together to share ideas.”

 

Michael Brown, MD, Nobel prize winner and renowned researcher 

Fund Research with the OSI

To take a bigger step in osteosarcoma advocacy, you can create your own osteosarcoma science fund with our support and infrastructure. Through a Partnering for Progress fund, we help you determine a research study or trial to support, and we handle many of the logistics, allowing you to focus on reaching out to friends and family to make a difference for osteosarcoma patients everywhere.

If you are interested in learning more about Partnering for Progress, please email giving@osinst.org and our Development Manager, Vanessa Peterson, will be in touch.

Concentrate on the Cure with Us

The Osteosarcoma Institute’s mission is to dramatically increase treatment options and survival rates in osteosarcoma patients through identifying and funding the most promising and breakthrough osteosarcoma clinical trials and science.