Researcher Resources
Who We Work With
What We Fund
Clinical Trials
A clinical study with osteosarcoma patients is the culmination and ultimate test for often years of translational science work. We prioritize novel approaches that have strong preclinical rationales and utilize an innovative trial model that allows a rapid readout of effectiveness.
Correlative Science
Clinical trials are focused on determining whether an experimental therapy works so they usually do not include funding to study why the treatment does or does not work. Such correlative studies can add a valuable additional level of understanding to inform future development.
Preclinical/Translational Studies
Osteosarcoma is a complex, poorly understood cancer. We seek out projects that will generate seminal preclinical biological insights and suggest new ways to attack the disease.
High-Risk/High-Impact
This grant program is for bold new ideas that may fall within any part of a drug development path, and that seek to deliver curative outcomes to patients with osteosarcoma.
Katherine Janeway, MD, OSI Strategic Advisory Board member, treating a patient
Annual Grants
The Osteosarcoma Institute’s 2026-2027 Grant Cycle is now open for Clinical Trials, Correlative Science, Preclinical/Translational, and High-Risk/High-Impact grant programs! You may download the 2026-2027 OSI Grant Cycle Instructions document below that provides full details on the application process. The Letter of Intent (LOI) submission deadline is Thursday, September 10, 2026 by 12:00 p.m. Eastern Time. Invitations to submit a full proposal will be sent to applicants in December 2026. Funding decisions will be sent to all applicants in June 2027.
Off-Cycle Grants
While OSI’s annual Grant Cycle is our primary funding mechanism, we recognize that important scientific opportunities do not always align with the annual application timeline. Off-Cycle Grants provide investigators with an opportunity to request consideration for projects involving exceptional scientific opportunities that cannot reasonably wait until the next annual Grant Cycle. These opportunities may arise because of a time-sensitive discovery, rapidly evolving scientific developments, or other unique circumstances where delaying the work would significantly reduce the project’s potential impact. Proposals are reviewed on a case-by-case basis, based on scientific merit, alignment with OSI’s mission, the urgency of the scientific opportunity, and available funding.
Please email a 1–2-page summary of your proposed project to submissions@osinst.org. The summary should briefly describe the proposed research, explain why the opportunity is time sensitive, and outline why it cannot reasonably wait until the next annual Grant Cycle. We will review your inquiry and determine whether the proposed project is appropriate for consideration.