Advancing Crucial Understanding of Osteosarcoma

Institutional Collaborators

To OSI, No New Options is Not an Option

There have been no new treatment options approved for osteosarcoma in nearly 40 years. This is not acceptable to the Osteosarcoma Institute. Our healthcare visionaries, founders, staff, and board members have all been impacted by osteosarcoma in their personal lives and careers. We are taking on the persistent problem of osteosarcoma with urgency and a new approach because we care deeply about this mission.

It’s not because it’s the right thing to do, it’s because it’s unacceptable not to do it. 
-Mac Tichenor, OSI President

The Osteosarcoma Institute’s mission is to dramatically increase treatment options and survival rates in osteosarcoma patients through identifying and funding the most promising and breakthrough osteosarcoma clinical trials and science. The Osteosarcoma Institute funds breakthrough clinical trials and science to identify new treatments, and ultimately a cure for osteosarcoma.

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Our Impact

Funding, removing obstacles, raising awareness & working together. The Osteosarcoma Institute funds breakthrough clinical trials and science to identify new treatments, and ultimately a cure for osteosarcoma.


to Translational Science


to Clinical Trials


to Correlative Research


to Patient Support


Find information on our funded work, grants to translate scientific discoveries into new thereapies, and osteosarcoma science to identify new treatment options for osteosarcoma patients for whom first-line therapy has failed.


Osteosarcoma patients shouldn’t have to face the reality that no new treatments have been approved for OS in almost 40 years. Find information on how we’re supporting patients through the OSI Hotline and pursuing strategies to capitalize on the latest developments in improving the outcomes for patients.

Our Story

The OSI was initially conceived at an osteosarcoma expert panel conference held in Jackson Hole, Wyoming in the summer of 2015. Over the course of the conference, the evidence showed that there had been no progress in osteosarcoma treatments over the past ten years (in fact, over the past 35 years). A stark consensus emerged that the existing, traditional paradigm for seeking advancements had failed and a new paradigm was needed.

OSI Connect

(formerly OSI Hotline)

OSI Connect (formerly OSI Hotline) is a free resource for patients who have been diagnosed with osteosarcoma or suffered a relapse after initial treatment. This resource will help patients, families, and caregivers find answers to their questions from experienced, knowledgeable osteosarcoma expert physicians about all aspects of the disease, including available treatments and possible side effects, as well as helpful advice for getting the most out of your visits with your treating physician. Se Habla Español.

Colette R.

Mother of Osteosarcoma Patient

“OSI Connect is an amazing resource for our family! As a mother with a 13 year old osteowarrior, I couldn’t rest without knowing I am doing absolutely everything to give her the best care. OSI Connect gave me that peace of mind and the reassurance that I’m doing everything possible for my daughter. They are knowledgeable, kind and compassionate. I can’t thank the Osteosarcoma Institute enough for providing this service.”

Nicole K.

Mother of Osteosarcoma Patient

“My son, Gavin, was diagnosed with osteosarcoma in January of 2020. He began MAP treatment before the cancer unfortunately metastasized to his lungs. We reached out to OSI Connect for guidance and support as we searched for our next treatment option for Gavin. Thanks to the help from the experts at OSI, we were able to be connected with MD Anderson almost immediately. His and our journey with osteosarcoma is not over, but he is doing well, and it is so wonderful to see him smile. Our family is so grateful to have access to this free service. The OSI has become like an extended care team for Gavin, and I am comforted knowing that we have support from this group of osteosarcoma expert physicians.”

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