Meet Fernanda Arnaldez, MD, One of OSI’s Newest Strategic Advisory Board Members
With more than 20 years of expertise studying rare diseases, Dr. Arnaldez is working to remove barriers to developing osteosarcoma treatments.
“My passion lies in improving outcomes for those affected by cancer and contributing to new and better therapies.” Dr. Fernanda Arnaldez
There aren’t too many physicians who have worked on the academic research side and the drug development side. That’s what makes Fernanda Arnaldez, MD, such a unique addition to Osteosarcoma Institute’s Strategy Advisory Board. A natural leader, Dr. Arnaldez, executive global product leader for AstraZeneca, has spent more than 20 years on rare disease research. It is work that she finds equally challenging and gratifying. “My passion lies in improving outcomes for those affected by cancer and contributing to new and better therapies,” says Dr. Arnaldez, who leads several teams in pediatric oncology research and development — all the way from preclinical to proof of concept. Previously, Dr. Arnaldez was the investigator in the Investigational Drug Branch – Cancer Therapy Evaluation Program of the Division of Cancer Treatment and Diagnosis at the National Cancer Institute (NCI), and an associate research physician in the Pediatric Oncology Branch of the NCI. She specializes in rare solid malignancies in children and adolescents and previously acted as the Director of the NIH Pediatric and Wild-Type Gastrointestinal Stromal Tumor (GIST) Clinic. In 2021, Dr. Arnaldez joined OSI’s Strategy Advisory Board, a role she undertook with profound gratitude and responsibility. “I joined because I felt my values were represented in OSI’s mission,” she says. “This is a group of people that have the same passion, the same vision as I do. We all have seen — whether professionally or personally — children die of osteosarcoma, and that has to change.”
Dr. Fernanda Arnaldez

Addressing inherent challenges

Rare diseases have struggled with drug development for many different reasons. Funding is a big challenge, however, Dr. Arnaldez admits it is not the only one. “Funding helps a lot, but there are other things like logistics and access, as well as the difficulty of evaluating the mechanisms of disease, that make osteosarcoma and other rare diseases really hard,” she says. “Difficult things require a lot of collaboration. That is one of the things I like about the OSI — it’s akin to building bridges and trying to fill in the gaps. We need to synergize to make it happen. And I am optimistic.” Her optimism lies in how technology has evolved over the years, especially in the ability to analyze and read mass quantities of data. Dr. Arnaldez is a firm believer in the application of advancements like artificial intelligence that can be used for pattern recognition and digital pathology as well as expanding biomarkers and how they are used to diagnose osteosarcoma. “The more you learn about the mechanisms of disease,” she says, “the better off you are to implement prevention or therapeutics or symptomatic management.”

Belief in the mission

Dr. Arnaldez decided to become a pediatrician after realizing the deep relationship that families establish with the doctors caring for their youngest. “Further along in my career, I was privileged to witness the incredible resilience that families affected by pediatric cancer possess,” she says. “I was determined to contribute to improving outcomes for those affected by cancer and bring to the clinic innovative therapies, and to be able to have a meaningful impact in their lives.”

Bringing a different perspective

As a board member, Dr. Arnaldez brings her acute sense of decision-making and proficiency for things like logistics and strategy. Thanks to her hybrid career in academia and pharmaceuticals, she is able to provide guidance on whether a clinical trial or project should be pursued. In addition to this collaboration, Dr. Arnaldez also lends her expertise to OSI’s grant cycle review process. “OSI’s grant program is incredible because they are willing to take high, calculated risks for high rewards,” she says. “When you get these grants that do just that, it’s amazing.” “It’s a privilege to have the opportunity to interact with all these brilliant and inspiring people who are so close to my heart and whom I hold in such high esteem,” she continues. “OSI has a very clear vision and, not surprisingly, the bar is very high — nothing less than the cure [for osteosarcoma] is going to cut it. And I buy into that. It’s contagious and inspiring.”
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